H13N8 HA (His Tag) recombinant protein

H13N8 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

C-H-RAS; SPH; C-HA-RAS1; SPNA1; HA; CTLO; C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX; RASH1; AF093576; HRAS1; AI451697; IHJ; NMF4; P21RAS

Q5DL26

HA

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Lys 528) of the influenza A hemagglutinin H13N8 (A/black-headed gull/Netherlands/ 1/00 (H13N8)) (AAV91212.1), (HA1+HA2, uncleaved) was expressed, fused with a C-terminal polyhistidine tag.

H13N8

The secreted recombinant influenza A H13N8 HA (A/black-headed gull/Netherlands/1/00 (H13N8)) comprises 521 amino acids and has a predicted molecular mass of 58.5 kDa. As a result of glycosylation, the apparent molecular mass of the protein is approximately 60-70 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE