H8N4 HA (His Tag) recombinant protein

H8N4 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX; SPNA1; C-HA-RAS1; SPH; C-H-RAS; CTLO; HA; HRAS1; P21RAS; AI451697; IHJ; NMF4; AF093576; RASH1

Q20NH6

HA

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Lys 529) of the influenza A hemagglutinin (A/pintail duck/Alberta/114/1979 (H8N4)) (ABB87729.1) (HA1+HA2, uncleaved) was expressed, fused with a C-terminal polyhistidine tag.

H8N4

The secreted recombinant influenza A H8N4 HA (A/pintail duck/Alberta/114/1979 (H8N4)) comprises 523 amino acids and has a predicted molecular mass of 59.6 kDa. As a result of glycosylation, it migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE