H9N2 HA (His Tag) recombinant protein

H9N2 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

C-HA-RAS1; C-H-RAS; SPH; SPNA1; CTLO; HA; SPNA-1; C-BAS/HAS; H-RASIDX; HAMSV; RASH1; AF093576; HRAS1; NMF4; AI451697; IHJ; P21RAS

Q9Q0J0

Human Cells

A DNA sequence encoding the N-terminal segment (Met 1-Arg 338) of the influenza hemagglutinin (Influenza A virus (A/Chicken/Hong Kong/G9/97 (H9N2)) (AAF00701.1), termed as HA1, was fused with a polyhistidine tag at the C-terminus.

H9N2

The secreted recombinant HA1 subunit of influenza A H9N2 HA (Influenza A virus (A/Chicken/Hong Kong/G9/97(H9N2)) comprises 331 amino acids and has a predicted molecular mass of 37 kDa. As a result of glycosylation, it migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE