H1N1 HA (His Tag) recombinant protein

H1N1 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

RASH1; AF093576; AI451697; IHJ; NMF4; P21RAS; HRAS1; HA; CTLO; C-H-RAS; SPH; C-HA-RAS1; SPNA1; H-RASIDX; HAMSV; SPNA-1; C-BAS/HAS

B0VX44

HA

Human Cells

A DNA sequence encoding an N-terminal segment (Met 1-Arg 343) of Influenza A virus (A/Brisbane/59/2007 (H1N1)) (ACA28844.1) HA, termed as HA1 subunit, was fused with a polyhistidine tag at the C-terminus.

H1N1

Recombinant HA1 subunit of Influenza A virus (A/Brisbane/59/2007 (H1N1)) hemagglutinin consists of 337 amino acids and has a calculated molecular mass of 37.7 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 55-60 kDa protein in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE