H5N1 HA (His Tag) recombinant protein

H5N1 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

RASH1; AF093576; HRAS1; IHJ; AI451697; NMF4; P21RAS; C-HA-RAS1; SPH; C-H-RAS; SPNA1; CTLO; HA; C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX

Q1WDM0

HA

Human Cells

A DNA sequence encoding the the N-terminal segment (Met 1-Pro 337) of Influenza A virus H5N1 hemagglutinin (A/Anhui/1/2005 (H5N1) (ABD28180.1), termed as HA1, was fused with a polyhistidine tag at the C-terminus.

H5N1

The recombinant HA1 subunit of Influenza A virus H5N1 hemagglutinin (A/Anhui/1/2005 (H5N1) comprises 332 amino acids with the predicted molecular mass of 37.5 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE