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Product Name
H4N8 HA (His Tag) recombinant protein
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Description
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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Protein name
Hemagglutinin
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Protein short names
C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX; SPH; C-H-RAS; C-HA-RAS1; SPNA1; HA; CTLO; HRAS1; NMF4; AI451697; IHJ; P21RAS; RASH1; AF093576
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Uniprot ID
P19695
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Gene Name
HA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the N-terminal segment (Met 1-Arg 343) of the influenza hemagglutinin (A/chicken/Alabama/1/1975 (H4N8)) (P19695.1), termed as HA1, was fused with a polyhistidine tag at the C-terminus.
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Protein Species
H4N8
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Molecular weight
The secreted recombinant HA1 subunit of influenza A H1N1 HA (A/chicken/Alabama/1/1975(H4N8)) comprises 338 amino acids and has a predicted molecular mass of 37.6 kDa. As a result of glycosylation, it migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Influenza A H4N8 (A/chicken/Alabama/1/1975) Hemagglutinin Protein (HA1 Subunit) (His Tag) SDS-PAGE
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