H5N8 HA (His Tag) recombinant protein

Cat.#: 500846

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Product Information

  • Product Name
    H5N8 HA (His Tag) recombinant protein
  • Documents
  • Description
    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
  • Protein name
    Hemagglutinin
  • Protein short names
    AF093576; RASH1; HRAS1; P21RAS; AI451697; IHJ; NMF4; SPNA1; C-HA-RAS1; SPH; C-H-RAS; CTLO; HA; C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX
  • Uniprot ID
    A0A023JQ18
  • Gene Name
    HA
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Influenza A virus (A/duck/Zhejiang/6D18/2013 (H5N8)) hemagglutinin (AHM24058.1) (Met1-Lys341), termed as HA1, was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    H5N8
  • Molecular weight
    The recombinant HA1 subunit of the Influenza A virus (A/duck/Zhejiang/6D18/2013 (H5N8)) hemagglutinin consists 336 amino acids and predicts a molecular mass of 38.1 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Influenza A H5N8 (A/duck/Zhejiang/6D18/2013) Hemagglutinin / HA1 Protein (His Tag)

    Influenza A H5N8 (A/duck/Zhejiang/6D18/2013) Hemagglutinin / HA1 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"