H7N7 HA (His Tag) recombinant protein

H7N7 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

P21RAS; AI451697; NMF4; IHJ; HRAS1; AF093576; RASH1; HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1; HA; CTLO; SPNA1; C-H-RAS; SPH; C-HA-RAS1

Q6VMK2

HA

Human Cells

A DNA sequence encoding an N-terminal segment (Met 1-Arg 344) of Influenza A virus (A/chicken/Netherlands/1/03 (H7N7)) hemagglutinin (AAR02639.1), termed as HA1, was fused with a polyhistidine tag at the C-terminus.

H7N7

The recombinant HA1 subunit of Influenza A virus (A/chicken/Netherlands/1/03 (H7N7)) hemagglutinin comprises 331 amino acids and has a calculated molecular mass of 36.4 kDa. It migrates as an approximtely 47 kDa band in SDS-PAGE under reducing conditions due to glycosylation.

> 97 % as determined by SDS-PAGE