H3N2 HA (His Tag) recombinant protein

H3N2 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

RASH1; AF093576; NMF4; AI451697; IHJ; P21RAS; HRAS1; CTLO; HA; C-H-RAS; SPH; C-HA-RAS1; SPNA1; HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1

P03438

HA

Human Cells

A DNA sequence encoding the influenza A virus (A/X-31 (H3N2)) hemagglutinin (P03438) (Met1-Trp530), termed as HA, was fused with a polyhistidine tag at the C-terminus.

H3N2

The secreted recombinant HA subunit of influenza A virus (A/X-31 (H3N2)) comprises 525 amino acids and has a predicted molecular mass of 59.1 kDa. It migrates as approximately 71.3 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE