H5N1 HA (His Tag) recombinant protein
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Protein short names
SPNA1; SPH; C-H-RAS; C-HA-RAS1; HA; CTLO; AF093576; RASH1; C-BAS/HAS; SPNA-1; HRAS1; HAMSV; H-RASIDX; P21RAS; IHJ; AI451697; NMF4
A DNA sequence encoding the Influenza A virus (A/chicken/Jilin/9/2004(H5N1)) hemagglutinin (AAT76166.1) (Met1-Gln531), termed as HA, was expressed with a polyhistidine tag at the C-terminus.
The recombinant hemagglutinin of Influenza A virus (A/chicken/Jilin/9/2004(H5N1)) hemagglutinin consists 526 amino acids and predicts a molecular mass of 60.1 kDa.
> 95 % as determined by SDS-PAGE.
Measured by its ability to agglutinate guinea pig red blood cells.
HA titer is 0.1-0.5μg/mL for 1%GRBC
Influenza A H5N1 (A/chicken/Jilin/9/2004) Hemagglutinin / HA Protein (His Tag)
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