H3N2 HA (His Tag) recombinant protein

H3N2 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).

Hemagglutinin

RASH1; AF093576; HRAS1; NMF4; AI451697; IHJ; P21RAS; SPH; C-H-RAS; C-HA-RAS1; SPNA1; HA; CTLO; C-BAS/HAS; SPNA-1; HAMSV; H-RASIDX

A8W8K8

HA

Human Cells

A DNA sequence encoding the extracellular domain of Influenza A virus (A/Brisbane/10/2007 (H3N2)) (ABW23353.1) hemagglutinin (Met 1-Ile 531) (Native, HA1+HA2, uncleaved) was expressed with a C-terminal polyhistidine.

H3N2

The secreted recombinant hemagglutinin of Influenza A virus (A/Brisbane/10/2007 (H3N2)) comprises 526 amino acids with the predicted molecular mass of 59 kDa. As a result of glycosylation, it migrates as an approximately 90-100 kDa band in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE