H5N1 HA (His Tag) recombinant protein
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Protein short names
AI451697; IHJ; NMF4; P21RAS; HRAS1; RASH1; AF093576; HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1; CTLO; HA; C-H-RAS; SPH; C-HA-RAS1; SPNA1
A DNA sequence encoding the extracellular domain (Met 1-Gln 531) of the influenza A H5N1 hemagglutinin (A/goose/Guiyang/337/2006 (H5N1)) (ABJ96698.1), (HA1+HA2, uncleaved, cleavage site mutated (RRRKKR-TETR) was expressed, fused with a C-terminal polyhistidine tag.
The secreted recombinant influenza A H5N1 HA (A/goose/Guiyang/337/2006 (H5N1)) comprises 524 amino acids and has a predicted molecular mass of 59.6 kDa. As a result of glycosylation, it migrates as an approximately 65-75 kDa band in SDS-PAGE under reducing conditions.
> 97 % as determined by SDS-PAGE
Influenza A H5N1 (A/goose/Guiyang/337/2006) Hemagglutinin / HA Protein (His Tag) SDS-PAGE
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