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  • H5N1 HA (His Tag) recombinant protein

H5N1 HA (His Tag) recombinant protein

Cat.#: 500251

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Product Information

  • Product Name
    H5N1 HA (His Tag) recombinant protein
  • Documents
  • Description
    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
  • Protein name
    Hemagglutinin
  • Protein short names
    AI451697; IHJ; NMF4; P21RAS; HRAS1; RASH1; AF093576; HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1; CTLO; HA; C-H-RAS; SPH; C-HA-RAS1; SPNA1
  • Uniprot ID
    A0FFQ6
  • Gene Name
    HA
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Gln 531) of the influenza A H5N1 hemagglutinin (A/goose/Guiyang/337/2006 (H5N1)) (ABJ96698.1), (HA1+HA2, uncleaved, cleavage site mutated (RRRKKR-TETR) was expressed, fused with a C-terminal polyhistidine tag.
  • Protein Species
    H5N1
  • Molecular weight
    The secreted recombinant influenza A H5N1 HA (A/goose/Guiyang/337/2006 (H5N1)) comprises 524 amino acids and has a predicted molecular mass of 59.6 kDa. As a result of glycosylation, it migrates as an approximately 65-75 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Validations

    Influenza A H5N1 (A/goose/Guiyang/337/2006) Hemagglutinin / HA Protein (His Tag) SDS-PAGE

    Influenza A H5N1 (A/goose/Guiyang/337/2006) Hemagglutinin / HA Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"