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Product Name
H5N1 HA (His Tag) recombinant protein
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Description
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
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Protein name
Hemagglutinin
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Protein short names
C-HA-RAS1; C-H-RAS; SPH; SPNA1; HA; CTLO; SPNA-1; C-BAS/HAS; H-RASIDX; HAMSV; RASH1; AF093576; HRAS1; NMF4; AI451697; IHJ; P21RAS
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Uniprot ID
A5A5I3
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Gene Name
HA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Gln 531) of the influenza A H5N1 Hemagglutinin (A/Egypt/2321-NAMRU3/2007) (ABP96850.1) (HA1+HA2, uncleaved, with the cleavage site mutated (RRRKR-TETR) was expressed, fused with a C-terminal polyhistidine tag.
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Protein Species
H5N1
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Molecular weight
The secreted recombinant influenza A H5N1 HA (A/Egypt/2321-NAMRU3/2007 (H5N1)) comprises 524 amino acids and has a predicted molecular mass of 60 kDa. As a result of glycosylation, it migrates as an approximately 65-80 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Influenza A H5N1 (A/Egypt/2321-NAMRU3/2007) Hemagglutinin / HA Protein (His Tag) SDS-PAGE
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