H5N1 HA (His Tag) recombinant protein

H5N1 HA (His Tag) recombinant protein

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Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Hemagglutinin

CTLO; HA; SPNA1; C-H-RAS; SPH; C-HA-RAS1; HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1; AF093576; RASH1; P21RAS; IHJ; AI451697; NMF4; HRAS1

Q195D4

HA

Baculovirus-Insect Cells

A DNA sequence encoding the Influenza A virus (A/bar-headed goose/Qinghai/1A/2005(H5N1)) hemagglutinin (ABF93441.1) (Met1-Gln527), termed as HA, was expressed with a polyhistidine tag at the C-terminus.

H5N1

The recombinant HA subunit of iInfluenza A virus (A/bar-headed goose/Qinghai/1A/2005(H5N1) consists 522 amino acids and predicts a molecular mass of 59.6 kDa.

> 95 % as determined by SDS-PAGE.

1. Measured by its ability to bind with Neu5Aca2-3Galb1-4GlcNAcb-PAA-biotin (01-077) using the Octet RED System.
2. Measured by its ability to agglutinate guinea pig red blood cells. HA titer is 0.1-0.6 μg/mL for 1% GRBC.