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Human HSPA8/HSC70 (His Tag) recombinant protein

Cat.#: 500809

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Product Information

  • Product Name
    Human HSPA8/HSC70 (His Tag) recombinant protein
  • Documents
  • Description
    Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
  • Protein name
    Heat shock cognate 71 kDa protein
  • Protein short names
    HSP71; HSC71; HSP73; HEL-33; HEL-S-72P; HSC70; MGC131511; HSC54; MGC29929; LAP1; HSPA10; MGC114311; LAP-1; NIP71; 2410008N15RIK; HSC73; HSPA8
  • Uniprot ID
    P11142
  • Gene Name
    HSPA8; HSC70; HSP73; HSPA10
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human HSPA8 (P11142-1) (Met 1-Asp 646) was expressed, with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human HSPA8 consisting of 657 amino acids and has a calculated molecular mass of 72.4 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human HSPA8 / HSC70 Protein (His Tag) SDS-PAGE

    Human HSPA8 / HSC70 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"