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HCV NS3 protease / helicase (aa 1356-1459, GST Tag) recombinant protein

Cat.#: 504440

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Product Information

  • Product Name
    HCV NS3 protease / helicase (aa 1356-1459, GST Tag) recombinant protein
  • Documents
  • Description
    HCV NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS.\
  • Uniprot ID
    A0A0A7HBI9
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Hepatitis C virus (HCV)(serotype 1a, isolate H77) NS3 (NP_803144.1) (Thr1356-Thr1459) was expressed with a GST tag at the N-terminus.
  • Protein Species
    HCV
  • Molecular weight
    The recombinant Hepatitis C virus (HCV)(serotype 1a, isolate H77) NS3 consists 335 amino acids and predicts a molecular mass of 37.9 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Hepatitis C virus (HCV-1a) NS3 protease / helicase immunodominant region Protein (aa 1356-1459, GST Tag)

    Hepatitis C virus (HCV-1a) NS3 protease / helicase immunodominant region Protein (aa 1356-1459, GST Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"