• HBD1 peptide

HBD1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319295

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Optional Service: TFA RemovalWhat's this?

Special Price 118.9 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    HBD1 peptide
  • Documents
  • Sequence
    H-CKHHLGLEEPKKLR-OH
  • Three letter code
    H-Cys-Lys-His-His-Leu-Gly-Leu-Glu-Glu-Pro-Lys-Lys-Leu-Arg-OH
  • Length (aa)
    14
  • Peptide Purity (HPLC)
    95.88%
  • Molecular Formula
    C74H126N24O19S
  • Molecular Weight
    1688
  • Source
    Synthetic
  • Additional Information
    The peptide HBD1 is a synthetic peptide that contains the heparin-binding domain 1 of human insulin-like growth factor binding protein-2 (IGFBP-2). It has been shown to stimulate bone formation and increase bone mass in ovariectomized rats. There are some key points about its application prospect: Peptide HBD1 has potential as a therapeutic agent for treating osteoporosis and other bone-related disorders. The peptide has been shown to be effective in increasing bone mass in estrogen-deficient animals, which suggests that it may be useful for treating postmenopausal osteoporosis. Peptide HBD1 may be used in combination with other bone-building agents, such as parathyroid hormone (PTH), to enhance their effects. The pegylated form of peptide HBD1 has been shown to have a reversing dose response curve in stimulating osteoblast differentiation, which suggests that it may have potential as a drug delivery system for other bone-building agents.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Xi G, Wai C, Rosen CJ, Clemmons DR. A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats. Bone Res. 2018 Aug 14;6:23. doi: 10.1038/s41413-018-0024-9. PMID: 30109160; PMCID: PMC6089876.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"