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  • Hainanenin 1 peptide

Hainanenin 1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 302091

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Product Information

  • Product Name
    Hainanenin 1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FALGAVTKLLPSLLCMITRKC (Disulfide bridge: Cys15- Cys21)
  • Sequence
    Phe-Ala-Leu-Gly-Ala-Val-Thr-Lys-Leu-Leu-Pro-Ser-Leu-Leu-Cys-Met-Ile-Thr-Arg-Lys-Cys (Disulfide bridge: Cys15- Cys21)
  • Length (aa)
    21
  • Peptide Purity (HPLC)
    96.8%
  • Molecular Weight
    2276.92
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Hainanenin-1 is a 21-amino acid antimicrobial peptide originally purified from the skin secretion of the Hainan cascade-frog, Amolops hainanensis. It belongs to the hainanenin family, a novel group of amphibian antimicrobial peptides characterized by a C-terminal disulphide loop of seven residues formed between Cys15 and Cys21. The peptide contains three basic residues (two lysines and one arginine) with no acidic residues, resulting in a net charge of +3. Structural analysis indicates that hainanenin-1 adopts an amphipathic alpha-helical conformation, a feature common among many antimicrobial peptides and considered important for their biological function.
    Hainanenin-1 exhibits strong and broad-spectrum antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi, including several resistant strains. It also displays slight antioxidant activity in DPPH free radical scavenging assays, but shows relatively strong hemolytic activity on human erythrocytes. The discovery of hainanenin-1 increases the diversity of known amphibian antimicrobial peptides and provides new structural templates for anti-infective agent design.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Zhang S, Guo H, Shi F, et al. Hainanenins: a novel family of antimicrobial peptides with strong activity from Hainan cascade-frog, Amolops hainanensis. Peptides. 2012;33(2):251-7.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"