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  • H3K4(Me2) (1-20) peptide

H3K4(Me2) (1-20) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319777

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* Buy 1 get 1 free (?) What is TFA?

Special Price 579.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    H3K4(Me2) (1-20) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    ART-{Lys(Me2)}-QTARKSTGGKAPRKQL
  • Sequence
    Ala-Arg-Thr-{Lys(Me2)}-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C93H171N35O27
  • Molecular Weight
    2211.61
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The H3K4(Me2) (1-20) peptide is a histone H3-derived peptide encompassing residues 1 to 20, featuring dimethylation at lysine 4 (H3K4me2). This post-translational modification is associated with active gene transcription and plays a critical role in chromatin structure and function. H3K4me2 is recognized by various chromatin-associated proteins and serves as a key epigenetic mark for transcriptional regulation.

    The dimethylation of H3K4 is catalyzed by specific histone methyltransferases and is part of a dynamic process that includes mono- and trimethylation states. The presence of H3K4me2 is often found near the promoters of actively transcribed genes, facilitating the recruitment of transcriptional machinery and other regulatory complexes to modulate gene expression.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Mulder KW, Brenkman AB, Inagaki A, van den Broek NJ, Timmers HT. Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res. 2007;35(7):2428-39. doi: 10.1093/nar/gkm175. Epub 2007 Mar 28. PMID: 17392337; PMCID: PMC1874646.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"