Mouse BMP-3b/GDF-10 (Fc Tag) recombinant protein
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809).
Growth/differentiation factor 10
Protein short names
RP11-463P17.5; GDF-10; GDF10; BMP3B; BMP-3B
A DNA sequence encoding the mature form of mouse GDF10 (NP_665684.2) (Gln 367-Arg 476) was fused with the Fc region of human IgG1 at the N-terminus.
The recombinant mouse GDF10/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 370 amino acids and has a predicted molecular mass of 40.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmGDF10/Fc monomer is approximately 45 kDa.
> 95 % as determined by SDS-PAGE
Mouse BMP-3b / GDF-10 Protein (Fc Tag) SDS-PAGE
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