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Product Name
Human Glypican 3/GPC3/OCI-5 (His Tag) recombinant protein
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Description
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
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Protein name
Glypican-3
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Protein short names
SGB; SGBS; DGSX; MXR7; SDYS; GTR2-2; GPC3; SGBS1; AC002420.1; GLYPICAN 3; RP23-33P21.1; OCI-5
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Uniprot ID
P51654
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Gene Name
GPC3; OCI5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human GPC3 (P51654-1) (Met 1-His 559) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human GPC3 comprises 546 amino acids and has a predicted molecular mass of 62 kDa.
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Purity
> 87 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human GPC3 at 5 μg/ml (100 μl/well) can bind human bFGF / FGF2 with a linear ranger of 0.156-2.5 ng/ml.
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Validations
Human Glypican 3 / GPC3 / OCI-5 Protein (His Tag) SDS-PAGE
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