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Product Name
CyCMV/CMV Cytomegalovirus Glycoprotein B (Fc Tag)
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Description
Human cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 907-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.
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Protein name
Glycoprotein B
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Protein short names
CYTOMEGALOVIRUS GLYCOPROTEIN B; CMV GB; GB
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Uniprot ID
E7DB34
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the macaca fascicularis cytomegalovirus (CyCMV)(strain OT-1) glycoprotein B(gB) (ADV35145.1) (Met1-Asp680, with cleavage site mutated ‘RHKR’ to ‘TTQT’) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
CyCMV
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Molecular weight
The recombinant macaca fascicularis cytomegalovirus (CyCMV)(strain OT-1) glycoprotein B(gB) consists 899 amino acids and predicts a molecular mass of 102.5 kDa.
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Purity
> 90 % as determined by SDS-PAGE.
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Validations
Macaca fascicularis Cytomegalovirus (CMV) (strain OT-1) glycoprotein B / GB Protein (Fc Tag)
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