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Product Name
Human GBA3 (His Tag) recombinant protein
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Description
"Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to the glycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
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Protein name
Glucosidase, beta, acid 3 (Cytosolic)
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Protein short names
GBA3; KLRP; MGC126878; CYTOSOLIC BETA-GLUCOSIDASE; CBGL1; MGC104276; GLUC
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Uniprot ID
Q9H227
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Gene Name
GBA3; hCG_40508
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human GBA3 (NP_066024.1) (Met 1-Leu 469) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GBA3 consists of 480 amino acids and predicts a molecular mass of 55 kDa. It migrates as an approximately 50 kDa band in SDS-PAGE in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to hydrolyze 4-methylumbelliferyl-β-D glucopyranoside. The specific activity is >1,500 pmoles/min/μg.
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Validations
Human GBA3 / CBGL1 Protein (His Tag) SDS-PAGE
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