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  • GH12 peptide

GH12 peptide

For research use only. We do not sell to patients.

Cat.#: 318937

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 92.6 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    GH12 peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-GLLWHLLHHLLH-NH2
  • Three letter code
    H-Gly-Leu-Leu-Trp-His-Leu-Leu-His-His-Leu-Leu-His-NH2
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    95.83
  • Molecular Formula
    C73H110N22O12
  • Molecular Weight
    1487.79
  • Source
    Synthetic
  • Additional Information
    GH12 (GLLWHLLHHLLH-NH2) is an amphipathic α-helical antimicrobial peptide against oral streptococci in vitro. The peptide showed bactericidal activity against oral streptococci, with minimum inhibitory concentrations ranging from 6.7 to 32.0 μg/ml. GH12 concentrations 4-fold higher than the minimum bactericidal concentration completely killed oral streptococci within 20 min. Treating oral streptococci with GH12 caused noticeable changes in bacterial viability and morphology based on confocal laser scanning microscopy and scanning electron microscopy.
  • Storage Guidelines
    Ideally GH12 peptide should be stored in a freezer at or below -9C. GH12 peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Wang, Y., Fan, Y., Zhou, Z., Tu, H., Ren, Q., Wang, X., Ding, L., Zhou, X., and Zhang, L. (2017) De novo Synthetic Short Antimicrobial Peptides against Cariogenic Bacteria. Arch. Oral Biol. 80, 41−50.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"