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Product Name
Human GFRA3 (His & Fc Tag) recombinant protein
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Description
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
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Protein name
GDNF family receptor alpha-3
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Protein short names
Y15110; GFR-ALPHA-3; GDNFR-ALPHA-3; GFRA3; GFRALPHA3; GDNFR3
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Uniprot ID
O60609
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Gene Name
GFRA3; UNQ339/PRO538/PRO3664
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human GFRa3 (NP_001487.2) (Met 1-Trp 382) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GFRa3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 599 amino acids and predicts a molecular mass of 67.3 kDa. As a result of glycosylation, the rh GFRa3/Fc monomer migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind mouse ARTN in a functional ELISA.
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Validations
Human GFRA3 / GFR-alpha-3 Protein (His & Fc Tag) SDS-PAGE
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