Cart 2
  • Gap 26 peptide

Gap 26 peptide

Not For Human Use, Lab Use Only.

Cat.#: 318992

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 117.7 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Gap 26 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-VCYDKSFPISHVR-OH
  • Sequence
    H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
  • Length (aa)
    13
  • Peptide Purity (HPLC)
    95.59%
  • Molecular Formula
    C70H107N19O19S
  • Molecular Weight
    1550.77
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Gap 26 is a connexin mimetic peptide corresponding to residues 63 - 75 of in the first extracellular loop of connexin 43, which inhibits currents carried by connexin43 hemichannels and gap junction channels. Gap 26 can accelerate wound healing and may have potential in the early treatment of spinal cord injury.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37 PMID: 12526886
    • Evans and Leybaert (2007) Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes. 14(6) 265 PMID: 18392994
    • Desplantez et al (2012) Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res. 65(5) 546 PMID: 22406236
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"