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Product Name
Human GPR56 (His Tag) recombinant protein
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Description
Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation.
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Protein name
G-protein coupled receptor 56
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Protein short names
CYT28; DKFZP781L1398; UNQ540/PRO1083; BFPP; GPR56; TM7LN4; TM7XN1
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Uniprot ID
Q9Y653
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Gene Name
GPR56; TM7LN4; TM7XN1; UNQ540/PRO1083
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human GPR56 isoform b (NP_958933.1) extracellular domain (Met 1-Val 342) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human GPR56 comprises 328 amino acids and has a predicted molecular mass of 37.4 kDa. As a result of glycosylation, the apparent molecular mass of rhGPR56 is approximately 50-60 kDa in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Validations
Human GPR56 / TM7LN4 Protein (His Tag) SDS-PAGE
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