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  • RSV RSV-F / Fusion Glycoprotein (His Tag)

RSV RSV-F / Fusion Glycoprotein (His Tag)

Cat.#: 502814

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Product Information

  • Product Name
    RSV RSV-F / Fusion Glycoprotein (His Tag)
  • Documents
  • Description
    During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767).
  • Protein name
    Fusion glycoprotein F0
  • Protein short names
    F; PROTEIN F; FUSION PROTEIN (F); RESPIRATORY SYNCYTIAL VIRUS; RSVGP08
  • Uniprot ID
    P03420
  • Gene Name
    F
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human RSV Fusion glycoprotein (AAB59858.1) (Met 1-Thr 529) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    RSV
  • Molecular weight
    The secreted recombinant human RSV-F comprises 518 amino acids with a predicted molecular mass of 58 kDa. The RSV F0 precursor protein is cleaved into the disulfide-linked F1 and F2 subunits. As a result of glycosylation, the apparent molecular mass of the protein is approximately 45-55 kDa and 18 kDa in SDS-PAGE under reducing conditions, corresponding to the two subunits respectively.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human RSV (A2) Fusion glycoprotein / RSV-F Protein (His Tag) SDS-PAGE

    Human RSV (A2) Fusion glycoprotein / RSV-F Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"