Recombinant FSP1 protein (His tag)

• DataSheet
• COA (Batch NP456485)
• Material Safety Data Sheets (MSDS)

Recombinant Human Ferroptosis Suppressor Protein 1 (FSP1) Fragment (aa 28-373) - A highly purified, stable protein fragment ideal for studying the molecular mechanisms of ferroptosis inhibition and oxidative stress response. This 346-amino acid fragment maintains key functional properties while offering enhanced solubility for structural and biochemical applications.

Ferroptosis Suppressor Protein 1 (FSP1), encoded by the AIFM2 gene, is a critical NAD(P)H-dependent oxidoreductase that functions as a key inhibitor of ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation. FSP1 operates in parallel to GPX4 to suppress phospholipid peroxidation through its ability to catalyze the reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, generating a potent lipophilic antioxidant that prevents lipid oxidative damage. Additionally, FSP1 acts as a warfarin-resistant vitamin K reductase, producing hydroquinone forms that serve as radical-trapping antioxidants. The protein demon

MNHKVHHHHH HGGSSQLQAL NVPFMLVDMK DSFHHNVAAL RASVETGFAK KTFISYSVTF KDNFRQGLVV GIDLKNQMVL
LQGGEALPFS HLILATGSTG PFPGKFNEVS SQQAAIQAYE DMVRQVQRSR FIVVVGGGSA GVEMAAEIKT EYPEKEVTLI
HSQVALADKE LLPSVRQEVK EILLRKGVQL LLSERVSNLE ELPLNEYREY IKVQTDKGTE VATNLVILCT GIKINSSAYR
KAFESRLASS GALRVNEHLQ VEGHSNVYAI GDCADVRTPK MAYLAGLHAN IAVANIVNSV KQRPLQAYKP GALTFLLSMG
RNDGVGQISG FYVGRLMVRL TKSRDLFVST SWKTMRQSPP