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  • Fraternine

Fraternine

Cat.#: 318845

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Optional Service: TFA RemovalWhat's this?

Special Price 268.9 USD

Availability: 3 weeks
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Product Information

  • Product Name
    Fraternine
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-LSFQQVKEKVCKVEAKIGKKLPFC-Amidation
  • Three letter code
    H-Leu-Ser-Phe-Gln-Gln-Val-Lys-Glu-Lys-Val-Cys-Lys-Val-Glu-Ala-Lys-Ile-Gly-Lys-Lys-Leu-Pro-Phe-Cys-Amidation, disulfide bond forms between Cys11 and Cys24
  • Length (aa)
    24
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C126H211N33O31S2
  • Molecular Weight
    2748.34
  • Source
    Synthetic
  • Additional Information
    Fraternine, a Novel Wasp Peptide, Protects against Motor Impairments in 6-OHDA Model of Parkinsonism. This peptide protected against some of the motor alterations and neuronal death in a 6-OHDA model of parkinsonism. The primary sequence of Fraternine showed a high percentage of identity (75%) with the peptide Sylverin isolated from the venom of the Protonectarina sylveirae wasp. Fraternine induced a dose-dependent antiparkinsonian effect in the Rotarod test. Fraternine does not cause motor alterations.
  • Storage Guidelines
    Ideally Fraternine should be stored in a freezer at or below -9C. Fraternine should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Biolchi AM, de Oliveira DGR, Amaral HO, Campos GAA, Gonu00e7alves JC, de Souza ACB, et al. Fraternine, a Novel Wasp Peptide, Protects against Motor Impairments in 6-OHDA Model of Parkinsonism. Toxins (Basel). 2020;12(9)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-LSFQQVKEKVCKVEAKIGKKLPFC-Amidation
  • Chemical Formula:C126H211N33O31S2
  • Sequence length:24
  • Extinction coefficient:120 M-1cm-1
  • GRAVY:-0.13
  • Mw average:2748.34
  • Theoretical pI:9.98
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"