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Product Name
Human FOLR2 (His Tag) recombinant protein
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Description
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
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Protein name
Folate receptor beta
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Protein short names
FBP2; FBP; FBP/PL-1; FR-BETA; FOLR2; FR-P3; FOLBP2; BETA-HFR; FOLBP-2
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Uniprot ID
P14207
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Gene Name
FOLR2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human FOLR2 (P14207-1) without the propeptide (Met 1-His 228) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human FOLR2 consists of 223 amino acids and predictes a molecular mass of 26 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh FOLR2 is approximately 30-35 kDa due to glycosylation.
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Purity
> 87 % as determined by SDS-PAGE
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Validations
Human FOLR2 / FBP Protein (His Tag) SDS-PAGE
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