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  • FK-13 peptide

FK-13 peptide

Not For Human Use, Lab Use Only.

Cat.#: 301017

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* Buy 1 get 1 free (?) What is TFA?

Special Price 164.50 USD

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Product Information

  • Product Name
    FK-13 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FKRIVQRIKDFLR
  • Sequence
    Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg
  • Length (aa)
    13
  • Peptide Purity (HPLC)
    96.6%
  • Molecular Formula
    C80H135N25O17
  • Molecular Weight
    1719.09
  • CAS No.
    717919-68-1
  • Source
    Synthetic
  • Form
    Powder
  • Description

    FK-13 is a short cationic antimicrobial peptide derived from the central region (residues 17 to 29) of the human cathelicidin LL-37. It represents a truncated fragment that retains core structural and functional properties. This peptide exhibits microbicidal activity against a range of microorganisms.

    Studies indicate that FK-13, particularly in its amidated form (FK-13-NH2), demonstrates significant inhibitory effects on microbial growth. Its mechanism is associated with its cationic and amphipathic nature, which facilitates interaction with microbial membranes. Compared to the full-length LL-37 peptide, shorter derivatives like FK-13 are noted for their efficient synthetic production and retained bioactivity profile.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Ramírez-Ledesma MG, Rodríguez MC, Alva-Murillo N, Avila EE. The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis. Parasitol Res. 2022 Dec;121(12):3503-3512. doi: 10.1007/s00436-022-07674-6. Epub 2022 Sep 29. PMID: 36171407.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"