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Recombinant FGD5 protein (His tag)

Cat.#: 545257

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Product Information

  • Product Name
    Recombinant FGD5 protein (His tag)
  • Documents
  • Description

    Recombinant FGD5 Fragment (891-1303) is a high-purity protein derived from Homo sapiens, encompassing the critical DH and PH1 domains. This fragment serves as an essential tool for investigating CDC42 activation, VEGF signaling, and cytoskeletal regulation in vascular endothelial cells, enabling targeted functional studies.

    The full-length FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) activates CDC42 by catalyzing GDP-GTP exchange, playing a pivotal role in VEGF-induced signaling pathways. It regulates angiogenesis in vascular endothelial cells by promoting network formation, directional migration, and proliferation, and contributes to actin cytoskeleton organization and cell shape modulation. FGD5 localizes to the cytoplasm, cytoskeleton, membrane ruffles, endoplasmic reticulum, Golgi apparatus, and early endosomes, with observed colocalization with F-actin in ruffles and vascular endothelial cadherin at cell-cell junctions in confluent HUVECs, underscoring its multifaceted involvement in c

  • Protein name
    FYVE, RhoGEF and PH domain-containing protein 5
  • Uniprot ID
    Q6ZNL6
  • Gene Name
    FGD5; ZFYVE23
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 891-1303 aa (Q6ZNL6) were fused with C-terminal 6His tag.
  • Sequence 
    MSRALVIAQE LLSSEKAYVE MLQHLNLDFH GAVMRALDDM DHEGRDTLAR EELRQGLSEL PAIHDLHQGI LEELEERLSN
WESQQKVADV FLAREQGFDH HATHILQFDR YLGLLSENCL HSPRLAAAVR EFEQSVQGGS QTAKHRLLRV VQRLFQYQVL
LTDYLNNLCP DSAEYDNTQG ALSLISKVTD RANDSMEQGE NLQKLVHIEH SVRGQGDLLQ PGREFLKEGT LMKVTGKNRR
PRHLFLMNDV LLYTYPQKDG KYRLKNTLAV ANMKVSRPVM EKVPYALKIE TSESCLMLSA SSCAERDEWY GCLSRALPED
YKAQALAAFH HSVEIRERLG VSLGERPPTL VPVTHVMMCM NCGCDFSLTL RRHHCHACGK IVCRNCSRNK YPLKYLKDRM
AKVCDGCFGE LKKRLEHHHH HH
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 48.79 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 50 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant FGD5 protein (His tag)

    Recombinant FGD5 protein (His tag)

    M: Marker; Lane 1: FGD5; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"