Recombinant FBX16 protein (His tag)

• DataSheet
• COA (Batch NP456459)
• Material Safety Data Sheets (MSDS)

Recombinant FBXO16 (F-box only protein 16) fragment (amino acids 1-164) from Homo sapiens, encompassing the critical F-box domain. This high-purity protein is an essential tool for investigating ubiquitin-mediated protein degradation pathways and domain-specific interactions in cellular regulation.

The full-length F-box only protein 16 (FBXO16) is encoded by the FBXO16 gene in humans and functions as a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Based on its functional summary, FBXO16 likely recognizes and binds phosphorylated protein substrates, promoting their ubiquitination and subsequent degradation by the proteasome. This targeted protein degradation mechanism plays a crucial role in regulating various cellular processes, including cell cycle progression, signal transduction, and protein quality control. The recombinant fragment (1-164) specifically contains the F-box domain (residues 86-132), which mediates interaction with SKP1 and is essen

MSKIKHHHHH HGGSMMAFAP PKNTDGPKMQ TKMSTWTPLN HQLLNDRVFE ERRALLGKWF DKWTDSQRRR ILTGLLERCS
LSQQKFCCRK LQEKIPAEAL DFTTKLPRVL SLYIFSFLDP RSLCRCAQVC WHWKNLAELD QLWMLKCLRF NWYINFSPTP
FEQGIWKKHY IQMVKELH