-
Product Name
Human FAIM3 (Fc Tag) recombinant protein
- Documents
-
Description
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
-
Protein name
Fas apoptotic inhibitory molecule 3
-
Protein short names
FC MU RECEPTOR; 1810037B05RIK; TOSO; FCMR; REGULATOR OF FAS-INDUCED APOPTOSIS TOSO; IMMUNOGLOBULIN MU FC RECEPTOR; FAS APOPTOTIC INHIBITORY MOLECULE 3; FAIM3; IGM FC RECEPTOR; FCMUR
-
Uniprot ID
O60667
-
Gene Name
FAIM3; TOSO
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human FAIM3 (NP_005440.1) (Met1-Gly251) was expressed with the Fc region of human IgG1 at the C-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human FAIM3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a predicted molecular mass of 53 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 65 % as determined by SDS-PAGE
-
Validations
Human FAIM3 Protein (Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"