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  • Esculentin-2-OR4 peptide

Esculentin-2-OR4 peptide

Not For Human Use, Lab Use Only.

Cat.#: 300579

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Product Information

  • Product Name
    Esculentin-2-OR4 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-GVFTLIKGATQLIGKTLGKELGKTGLELMACKITEQC-OH
  • Sequence
    H-Gly-Val-Phe-Thr-Leu-Ile-Lys-Gly-Ala-Thr-Gln-Leu-Ile-Gly-Lys-Thr-Leu-Gly-Lys-Glu-Leu-Gly-Lys-Thr-Gly-Leu-Glu-Leu-Met-Ala-Cys-Lys-Ile-Thr-Glu-Gln-Cys-OH (disulfide bond: Cys31-Cys37)
  • Length (aa)
    37
  • Peptide Purity (HPLC)
    95.23%
  • Molecular Formula
    C172H296N44O51S3
  • Molecular Weight
    3892.72
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Esculentin-2-OR4 is an antimicrobial peptide (AMP) identified from the skin secretions of the odorous frog Odorrana rotodora. It belongs to the Esculentin-2 family, a group of AMPs characterized by a conserved disulfide-bridged cyclic motif at the C-terminus. This peptide was isolated and characterized as part of a large-scale study on AMPs from nine species of Chinese odorous frogs, using a combination of peptidomic analysis and cDNA cloning techniques.

    The primary structure of Esculentin-2-OR4 was determined through Edman degradation and mass spectrometry, and its precursor was cloned from a skin AMP cDNA library. Like other members of the Esculentin-2 family, this peptide exhibits a typical precursor organization that includes a signal peptide, an acidic intervening segment, and the mature C-terminal peptide. Structural analysis classifies Esculentin-2-OR4 as a cyclic peptide due to the presence of a C-terminal disulfide bridge forming a heptapeptide loop, a feature common among ranid frog AMPs and termed the "Rana box."

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Yang X, Lee WH, Zhang Y. Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. J Proteome Res. 2012;11(1):306-19.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"