Eribulin Monoclonal Antibody

Eribulin Monoclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Product has been tested in direct ELISA.

ELISA

Chemical

Mouse IgG1, κ

Eribulin conjugated with BSA. Protein G affinity purified

Monoclonal

PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.

Store at -20℃. Avoid freeze / thaw cycles.

ELISA: 1:5,000-1:20,000

Eribulin is a synthetic analogue of halichondrin B which is a large polyether macrolide derived from a very strong natural mitotic tubule inhibitor. Eribulin acts by inhibiting the dynamics of the microtubules. It binds to the plus ends of the microtubules and suppresses the microtubule growth in the interphase cells without affecting the shortening phase and sequesters tubulin into nonproductive aggregates, leading to G2/M cell-cycle block and ultimately apoptosis after prolonged mitotic blockage. Its mechanism is distinct from other microtubule inhibitors like vinca alkaloids and taxanes, which affect both the shortening and growing phases.

• Watanabe K, Yui Y, Sasagawa S, Suzuki K, Kanamori M, Yasuda T, Kimura T. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174. doi: 10.18632/oncotarget.26536. PMID: 30719211; PMCID: PMC6349434.
• Okouneva T, Azarenko O, Wilson L, Littlefield BA, Jordan MA. Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther. 2008 Jul;7(7):2003-11. doi: 10.1158/1535-7163.MCT-08-0095. PMID: 18645010; PMCID: PMC2562299.