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Product Name
Human ERP27 (Fc Tag) recombinant protein
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Description
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartment. PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. Recombinant Human Protein Disulfide Isomerase is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. Recombinant PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. ERP27 is a widely expressed protein which localizes to the ER and may act as a protease, protein disulfide isomerase, thiol-disulfide oxidase or phospholipase. ERP27 doesn't contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.
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Protein name
Endoplasmic reticulum resident protein 27
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Protein short names
FLJ32115; MGC129515; PROTEIN DISULFIDE ISOMERASE FAMILY A; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27; 1810033M07RIK; UNQ781/PRO1575; MEMBER 8; ER PROTEIN 27; 1810047B09RIK; MGC129514; ENDOPLASMIC RETICULUM RESIDENT PROTEIN ERP27; PDIA8; C12ORF46; ENDOPLASMIC RETICULUM PROTEIN 27 KDA
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Uniprot ID
Q96DN0
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Gene Name
ERP27; C12orf46; UNQ781/PRO1575
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ERP27 (Q96DN0) (Glu26-Pro269) was fused with Fc region of mouse IgG at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ERP27/mFc is a disulfide-linked homodimer. The reduced monomer comprises 478 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 59 in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 84 % as determined by SDS-PAGE
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Validations
Human ERP27 Protein (Fc Tag) SDS-PAGE
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