• ERG inhibitory peptide 1(EIP1)

ERG inhibitory peptide 1(EIP1)

Not For Human Use, Lab Use Only.

Cat.#: 318717

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Product Information

  • Product Name
    ERG inhibitory peptide 1(EIP1)
  • Documents
  • Sequence
    H-LPPYLFT-NH2
  • Three letter code
    H-Leu-Pro-Pro-Tyr-Leu-Phe-Thr-NH2
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    97.2%
  • Molecular Formula
    C44H64N8O9
  • Molecular Weight
    849.02
  • Source
    Synthetic
  • Additional Information
    ERG inhibitory peptide 1, also known as EIP1 peptide was first reported in 'Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer, Cancer Cell (2017)' by Wang et al. EIP1 peptide comprising the amino acid sequence: LPPYLFT. The EIP1 (LPPYLFT) did not significantly match a known protein when aligned to the Swiss-Prot database (BLAST). EIP1 & EIP2 peptide could bind ERG with high affinity and specificity, leading to proteolytic degradation of the ERG protein. The EIPs attenuated ERG-mediated transcription, chromatin recruitment, protein-protein interactions, cell invasion and proliferation, and tumor growth.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Wang et al., Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer, Cancer Cell (2017), http://dx.doi.org/10.1016/j.ccell.2017.02.017
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"