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Product Name
E.coli rppH/nudH/ygdP/b2830/JW2798 recombinant protein
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Description
Messenger RNA (mRNA) degradation plays a key role in the control of gene expression in all organisms by limiting the number of times that each mRNA molecule can be used as a template for protein synthesis. RNA pyrophosphohydrolase, also called RppH, is a master regulator of 5'-dependent mRNA decay. It accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. RppH preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products, and can be able to hydrolyze diadenosine hexa- and tetra-phosphate. However, this protein has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, it has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.
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Protein name
RNA pyrophosphohydrolase(rppH)
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Protein short names
nudH; ygdP; b2830; JW2798
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Uniprot ID
P0A776
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the E.coli rppH/nudH/ygdP/b2830/JW2798 Met1-Gly176 is expressed.
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Protein Species
E.coli
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Purity
>95% as determined by SDS-PAGE.
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Validations
E.coli rppH/nudH/ygdP/b2830/JW2798 recombinant protein
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