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Product Name
Human DRAXIN/C1orf187 (His Tag) recombinant protein
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Description
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
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Protein name
Draxin
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Protein short names
UNQ3119; NEUCRIN; 2610109H07RIK; AGPA3119; C1ORF187
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Uniprot ID
Q8NBI3
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Gene Name
DRAXIN; C1orf187; PSEC0258; UNQ3119/PRO10268
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human DRAXIN (NP_940947.3) (Met1-Val349) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human DRAXIN consists of 335 amino acids and predicts a molecular mass of 37.5 KDa. It migrates as an approximately 52-58 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human DRAXIN Protein (His Tag) SDS-PAGE
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