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Product Name
Human ADAM12 (His Tag) recombinant protein
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Description
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
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Protein name
Disintegrin and metalloproteinase domain-containing protein 12
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Protein short names
RP11-295J3.5; MCMPMLTNA; ADAM12-OT1; MLTN; MLTNA; KIAA4001; MKIAA4001; ADAM12; MCMP; CAR10
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Uniprot ID
O43184
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Gene Name
ADAM12; MLTN; UNQ346/PRO545
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ADAM12 isoform 1 (NP_003465.3) extracellular domain (Met 1-Ser 513) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ADAM12 consists of 496 amino acids and predicts a molecular mass of 55.2 kDa. As a result of glycosylation, rhADAM12 migrates as three bands with apparent molecular mass of 27, 55 and 72 kDa corresponding to the propeptide, the mature form and the pro form respectively in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized human ADAM12-His (Cat: 501814) at 10 μg/ml (100 μl/well) can bind biotinylated mouse FLRG-His (Cat: 10591-M08H) with a linear range of 0.31-1.25 μg/ml. -
Validations
Human ADAM12 Protein (His Tag) SDS-PAGE
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