Cart 2
  • Diptericin peptide

Diptericin peptide

Not For Human Use, Lab Use Only.

Cat.#: 302194

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 468.00 USD

Availability: 5 working days
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Diptericin peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DLHIPPPDNKINWPQLSGGGGGSPKTGYDININAQQK
  • Sequence
    Asp-Leu-His-Ile-Pro-Pro-Pro-Asp-Asn-Lys-Ile-Asn-Trp-Pro-Gln-Leu-Ser-Gly-Gly-Gly-Gly-Gly-Ser-Pro-Lys-Thr-Gly-Tyr-Asp-Ile-Asn-Ile-Asn-Ala-Gln-Gln-Lys
  • Length (aa)
    37
  • Peptide Purity (HPLC)
    97.1%
  • Molecular Formula
    C173H268N50O55
  • Molecular Weight
    3928.26
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Diptericin is an antibacterial peptide originally isolated from the insect Phormia terranovae. It consists of an N-terminal domain with sequence homology to the proline-rich peptide drosocin and a C-terminal glycine-rich region similar to attacins. The peptide can be glycosylated, but studies on synthetic unglycosylated diptericin demonstrate that carbohydrate side chains are not required for its antibacterial activity.

    Diptericin exhibits a narrow spectrum of activity, primarily against specific Gram-negative bacteria such as Escherichia coli and Salmonella typhimurium at submicromolar concentrations. Its mode of action appears distinct from known classes of antibacterial peptides; it lacks an ordered secondary structure in aqueous solution as determined by nuclear magnetic resonance spectroscopy and circular dichroism, and it does not lyse mammalian cells. Furthermore, isolated N-terminal or C-terminal fragments are inactive, suggesting the full-length sequence is necessary for function.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Cudic M, Bulet P, Hoffmann R, Craik DJ, Otvos L Jr. Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur J Biochem. 1999 Dec;266(2):549-58. doi: 10.1046/j.1432-1327.1999.00894.x. PMID: 10561597.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"