• dg-Bcan-Targeting Peptide 7/BTP-7

dg-Bcan-Targeting Peptide 7/BTP-7

Not For Human Use, Lab Use Only.

Cat.#: 319549

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Optional Service: TFA RemovalWhat's this?

Special Price 188.4 USD

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Product Information

  • Product Name
    dg-Bcan-Targeting Peptide 7/BTP-7
  • Documents
  • Sequence
    H-tkwGhvnk-OH
  • Three letter code
    H-(D)-Thr-(D)-Lys-(D)-Trp-Gly-(D)-His-(D)-Val-(D)-Asn-(D)-Lys-OH
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    95.42%
  • Molecular Formula
    C44H68N14O11
  • Molecular Weight
    969.09
  • Source
    Synthetic
  • Additional Information
    dg-Bcan (a Brevican isoform lacking most glycosylation) is explored as a molecular target for GBM(Glioblastoma multiforme). BTP-7 binds dg-Bcan with high affinity and specificity. BTP-7 is preferentially internalized by dg-Bcan-expressing patient-derived GBM cells. BTP-7 represents a promising lead candidate for further development into novel imaging agents and targeted therapeutics.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • von Spreckelsen N, Fadzen CM, Hartrampf N, Ghotmi Y, Wolfe JM, Dubey S, Yang BY, Kijewski MF, Wang S, Farquhar C, Bergmann S, Zdioruk M, Wasserburg JR, Scott B, Murrell E, Bononi FC, Luyt LG, DiCarli M, Lamfers MLM, Ligon KL, Chiocca EA, Viapiano MS, Pentelute BL, Lawler SE, Cho CF. Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh). 2021 Apr;4(4):2000244. doi: 10.1002/adtp.202000244. Epub 2021 Jan 20. PMID: 33997269; PMCID: PMC8114962.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"