LHRH/GnRH peptide

LHRH/GnRH peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyr-HWSYGLRPG-NH2

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

9

97.5%

C₅₅H₇₅N₁₇O₁₃

1182.28

33515-09-2

638793

Synthetic

Powder

Luteinizing Hormone-Releasing Hormone (LH-RH) is a decapeptide originating from the hypothalamus that triggers the release of gonadotropins by interacting with specific receptors on pituitary cells. It plays a crucial role in regulating reproductive functions. Besides its role in the pituitary gland, LH-RH is found to have effects in peripheral organs like the prostate, endometrium, breast, and ovary, indicating its involvement in local tissue functions. LH-RH's presence has been noted in cancer cells and tumors of reproductive organs, suggesting a connection between LH-RH and conditions like prostate cancer and gynecological cancers, showcasing its significance beyond reproductive control.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Collado B, Carmena MJ, Cortés J, Schally AV, Prieto JC. Luteinizing hormone-releasing hormone antagonist Cetrorelix regulates the expression of Galphas and Galphai protein subunits and adenylate cyclase activity in rat ovary, breast and pituitary. Int J Oncol. 2004 Mar;24(3):725-30. PMID: 14767559.

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.