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Product Name
Human DMBT1/Muclin (His Tag) recombinant protein
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Description
May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.
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Protein name
Deleted in malignant brain tumors 1 protein
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Protein short names
CRP; HENSIN; APACTIN; DBMT1; GLYCOPROTEIN 300; GP340; GP300; CRP-DUCTIN; VOMEROGLANDIN; MGC164738; FLJ61058; P80; CRP-[B]; DMBT1; GP-340; RP11-481L19.1; SALIVARY AGGLUTININ; GLYCOPROTEIN 340; MUCLIN; CRPD; EBNERIN; CRP-[A]
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Uniprot ID
Q9UGM3
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Gene Name
DMBT1; GP340
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the N-terminal segment of human DMBT1 (NP_004397.2) (Met 1-Ser 220) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human DMBT1 consists of 211 amino acids and has a predicted molecular mass of 22.6 kDa. The apparent molecular mass of rh DMBT1 is approximately 35-45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant human Galectin-3 (Cat:10289-HNAE-E) at 10 μg/ml (100 μl/well) can bind biotinylated DMBT1-His (Cat:502044) with a linear range of 0.06-1.0 μg/ml. -
Validations
Human DMBT1 / Muclin Protein (His Tag) SDS-PAGE
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