Decoralin-NH2 peptide

Decoralin-NH2 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

H-SLLSLIRKLIT-NH2

H-Ser-Leu-Leu-Ser-Leu-Ile-Arg-Lys-Leu-Ile-Thr-NH2

11

95.79%

C₅₈H₁₁₀N₁₆O₁₄

1255.59

Synthetic

These factors are present in decoralin-NH2, but not in decoralin, which as a consequence, led to the lower helical content of decoralin than decoralin-NH2. However, when comparing decoralin versus anoplin, both in the amidated form, other structural features should be taken into account for this case. These features are principally related to the average hydrophobicity and hydrophobic moment, and the angle subtended by their polar faces. Anoplin presents a lower mean hydrophobic moment and mean hydrophobicity and higher polar angle than decoralin, these parameters would contribute to its lower helical content in the zwitterionic and in anionic vesicles compared to the decoralins. Moreover, these parameters taken together can also be correlated to the enhanced biological activities of decoralin-NH2 in relation to anoplin.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Konno, Katsuhiro et al. “Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus.” Peptides vol. 28,12 (2007): 2320-7.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues