Cynomolgus XEDAR/EDA2R (Fc Tag) recombinant protein

Cynomolgus XEDAR/EDA2R (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

UNQ2448/PRO5727/PRO34080; EDA2R; MGC124099; XEDAR; TNFRSF27; EDA-A2R; EDAA2R; RP23-188N15.1; 9430060M22RIK

Human Cells

A DNA sequence encoding the cynomolgus EDA2R (NP_001180396.1) (Met1-Glu136) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus EDA2R is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a calculated molecular mass of 42.1 KDa.The apparent molecular mass of the protein is approximately 116, 58 and 53 KDa respectively in SDS-PAGE.

(60.3+19.2+15) % as determined by SDS-PAGE