-
Product Name
Cynomolgus TIGIT/VSIG9/VSTM3 (His tag) recombinant protein
- Documents
-
Description
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
-
Protein name
T-cell immunoreceptor with Ig and ITIM domains
-
Protein short names
VSIG9; VSTM3
-
Uniprot ID
G7NXM4
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the Cynomolgus TIGIT/VSIG9/VSTM3 Met89-Pro209 is expressed with a 6His tag at the C-terminus.
-
Protein Species
Cynomolgus
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Cynomolgus TIGIT/VSIG9/VSTM3 (His tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"