Cynomolgus TGF-beta 1/TGFB1 (His Tag) recombinant protein

Cynomolgus TGF-beta 1/TGFB1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

TGFB; TGFB-1; TGFB1; TGFBETA; LAP; TGFBETA1; DPD1; TGF-BETA1; CED; TGF-BETA 1

Human Cells

A DNA sequence encoding the cynomolgus TGFB1 (Met1-Ser390) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus TGFB1 consists 372 amino acids and predicts a molecular mass of 42.7 kDa.

> 95 % as determined by SDS-PAGE.

1. Measured by its binding ability in a functional ELISA.
2. Immobilized Cynomolgus TGFB1-His at 10 μg/mL (100 μL/well) can bind Cynomolgus TGFBR2-Fc (Cat:502476). The EC₅₀ of Cynomolgus TGFBR2-Fc (Cat:502476) is 28-56 ng/mL.